UP165

UP165 is a **standardized extract derived from the leaves of Zea mays** (corn), standardized to contain **6-methoxybenzoxazolinone (6-MBOA)** as its bioactive component. It is marketed and clinically studied as a **dietary supplement for improving sleep quality, sleep efficiency, and mood** in healthy adults and subjects with mild anxiety and depression[1][2][3][5]. UP165 has shown efficacy in increasing deep sleep time, improving total sleep duration, and reducing psychological stress and mood disturbance, without typical sedative side effects[1][2][3][5]. The mechanism of action involves binding to **melatonin receptors MT1 and MT2 as a weak agonist**, stimulating melatonin biosynthesis (by upregulating enzymes such as tryptophan-5-hydroxylase and N-acetyltransferase), reducing the activity of liver tryptophan dioxygenase, **increasing endogenous serotonin and melatonin levels**, and promoting muscle relaxation[2][3][5]. UP165 is taken orally, with clinical studies using 250–500mg/day[1][2][3]. It is not a conventional pharmaceutical but a standardized nutraceutical supplement derived from corn leaf.

Brand names

Maizinol

Other names

Zea mays leaf extract standardized for 6-methoxybenzoxazolinonestandardized corn leaf extract6-MBOA extract