Drug intelligence / Profile preview

UP360

Development stage
Unknown
Lead developer
Unigen
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

UP360 is a proprietary botanical blend developed by Unigen Inc., composed of standardized polysaccharide and polyphenol extracts from *Aloe vera* gel, *Poria cocos* mushroom, and rosemary. Positioned as a nutraceutical ingredient for immune homeostasis, it exerts antioxidant, anti-inflammatory, and immunomodulatory effects. In a randomized, triple-blind, placebo-controlled clinical trial involving healthy adults receiving seasonal influenza vaccination, UP360 was shown to significantly increase influenza B-specific IgG antibodies and glutathione peroxidase levels, suggesting it supports a robust immune response and may help prevent flu and flu-like symptoms. The formulation specifically targets immune cell populations such as gamma delta T-cells and various lymphocyte subsets to maintain immune balance.

Other names
Aloe vera + Poria cocos + rosemary extract
02

Targets

γδ TCR (T-cell receptor)GPX4 (Glutathione peroxidase 4)

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