uPAR shRNA

uPAR shRNA is a gene-silencing tool that utilizes short hairpin RNA (shRNA) to specifically target the mRNA of the urokinase plasminogen activator receptor (uPAR, also known as CD87 or PLAUR). By inducing the RNA interference (RNAi) pathway, it leads to the degradation of uPAR transcripts and a subsequent reduction in uPAR protein levels. In the context of oncology research, particularly glioblastoma multiforme (GBM), uPAR shRNA is employed to study the receptor's role in promoting tumor cell migration, invasion, and angiogenesis. Preclinical studies have shown that knocking down uPAR can downregulate downstream signaling components like iNOS, Src, and FAK, thereby significantly reducing the aggressive phenotype of glioma cells in both in vitro assays and in vivo xenograft models.

Other names

urokinase plasminogen activator receptor shRNAPLAUR shRNAsh-uPAR