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UQP12

Development stage: Preclinical
Lead developer: BioGene Therapeutics
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Hydrogel Systems → Drug Delivery Systems, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Intranasal

Overview

UQP12 is a preclinical-stage siRNA therapeutic being developed by BioGene Therapeutics, a subsidiary of PreveCeutical Medical, for the treatment of diabetes and obesity. It utilizes "Smart-siRNA" technology designed to target and silence the mRNA of Protein Tyrosine Phosphatase 1B (PTP1B) in the brain. PTP1B is a negative regulator of insulin and leptin signaling; by inhibiting its expression, the drug aims to restore sensitivity to these hormones. The siRNA is encapsulated in bio-responsive lipid nanoparticles (bLNP) and delivered via an intranasal nose-to-brain nasal spray using a proprietary Sol-Gel platform to bypass the blood-brain barrier.

Targets

PTPN1 (Protein tyrosine phosphatase 1B)

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