urapidil

Urapidil is a small molecule antihypertensive drug primarily used for the treatment of essential hypertension and hypertensive emergencies. It acts as a selective postsynaptic alpha-1-adrenergic receptor antagonist, leading to vasodilation and reduced peripheral resistance. Additionally, urapidil stimulates central Serotonin 5-HT1A receptor, which contributes to its blood pressure-lowering effects without causing reflex tachycardia. Urapidil is effective both as monotherapy and in combination with other antihypertensives such as beta-blockers or thiazide diuretics. It has also been investigated for use in pre-eclampsia and perioperative hypertension management. Beyond its cardiovascular effects, urapidil demonstrates anti-inflammatory and antioxidant properties that may be beneficial in ischemia-reperfusion injuries[2][3][4][5][6][1]. Developed by Knoll, and manufactured by Takeda.

Brand names

Ebrantil

Other names

urapidil HClurapidil (hydrochloride)64887-14-5