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UriRoyal

Development stage: Unknown
Lead developer: PharmaS
Modality: Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Small Molecules, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration: Oral

Overview

UriRoyal is an oral over-the-counter dietary supplement from PharmaS for urinary tract health and prevention of recurrent uncomplicated urinary tract infections, particularly those associated with *Escherichia coli*. The marketed product is a combination formulation containing D-mannose together with probiotic cultures including *Saccharomyces boulardii* and *Streptococcus thermophilus*. Its proposed mechanism is primarily non-antibiotic: D-mannose can bind mannose-sensitive adhesins on uropathogenic *E. coli*, reducing bacterial adherence to the urothelium and facilitating washout during urination, while the probiotic components are positioned to support gastrointestinal and microbiome balance during or after antibiotic use. PharmaS presents UriRoyal as a consumer health product rather than an investigational prescription medicine.

Brand names: UriRoyal

Targets

FimH (Type 1 fimbrial adhesin)

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