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urokinase-derived peptide a6
- Development stage
- Phase 2
- Lead developer
- Angstrom Pharmaceuticals
- Modality
- Peptides
- Administration
- Subcutaneous
01
Overview
Urokinase-derived peptide A6 is an octapeptide (amino acids 136-143) derived from the proteolytic enzyme urokinase plasminogen activator (uPA), with potential antineoplastic activity. It has the sequence Acetyl-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2 with a molecular formula of C39H62N10O15 and molecular weight of approximately 911. A6 functions by interfering with the uPA/uPAR cascade and binds to CD44. It inhibits human microvascular endothelial cell migration but does not affect cell proliferation in vitro. The peptide has been investigated for treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma, and has shown inhibitory effects on choroidal neovascularization in animal models.
- Brand names
- Angstrom6Angstrom-6Angstrom 6
- Other names
- A6 PeptideA-6 PeptideA 6 Peptide
02
Targets
CD44 (CD44 antigen)
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