Urolithin A

Urolithin A is a naturally occurring small molecule metabolite produced by the transformation of ellagitannins (found in foods like pomegranates and walnuts) by gut microbiota[6][5]. It is not present in food directly but results from microbial metabolism. Urolithin A has demonstrated antioxidant and anti-inflammatory properties and acts as an activator of mitophagy—the selective degradation of mitochondria via autophagy—thereby improving mitochondrial function and cellular health[1][2][4]. Mechanistically, it activates pathways such as PINK1/Parkin-mediated mitophagy and modulates signaling through Nrf2 and AMPK/PPARγ[2]. Preclinical studies suggest benefits for muscle health (promoting muscle protein synthesis), neuroprotection (potentially relevant to Alzheimer’s disease), metabolic diseases (type 2 diabetes mellitus), cardiovascular health, anti-aging effects, and cancer prevention[2][5][7]. Urolithin A is being developed primarily as a dietary supplement for healthy aging; clinical development status includes early-phase human trials with no major safety concerns reported over short durations[4].

Brand names

TimelineTimeline NutritionTimeline Longevity

Other names

urolithin a3,8-dihydroxyurolithin3,8-hydroxydibenzo-alpha-pyrone