Drug intelligence / Profile preview

urtica dioica extract

Development stage
Phase 3
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**urtica dioica extract** is a botanical preparation derived from *Urtica dioica* and represents a heterogeneous herbal extract rather than a single defined molecular entity. It has been investigated as a traditional medicine, nutraceutical, and research-stage therapeutic for inflammatory disorders, benign prostatic hyperplasia, neurodegenerative conditions including Parkinson's disease, cardiovascular disorders, and some cancers. Reported bioactive constituents include polyphenols, flavonoids, phenolic acids such as caffeic acid derivatives, carotenoids, fatty acids, and amino acids. Its proposed pharmacology is pleiotropic and includes anti-inflammatory, antioxidant, and tissue-protective effects, with literature describing inhibition or down-modulation of cyclooxygenase activity, nuclear factor kappa B signaling, elastase and collagenase activity, and oxidative stress pathways rather than a single validated primary target. Because extract composition varies by plant part, extraction method, and product, mechanism, formulation, and clinical positioning are not standardized across studies.

Other names
stinging nettle extracturtica dioica leaf extractnettle extract
02

Targets

MMP12 (Macrophage Metalloelastase)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IL-6 (Interleukin 6)ELANE (Human Neutrophil Elastase)ElastaseNF-κBTNFA (Tumor necrosis factor alpha (soluble))

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