USP22 shRNA

USP22 shRNA is a gene silencing therapeutic designed to knockdown the expression of Ubiquitin-specific protease 22 (USP22) through RNA interference. USP22 is a deubiquitinating enzyme that plays a critical role in regulating protein stability, cell cycle progression, and oncogenic signaling pathways. In various cancer models, such as hepatocellular carcinoma and cholangiocarcinoma, USP22 is often upregulated and contributes to tumor growth, metastasis, and resistance to therapies like sorafenib. By silencing USP22, this shRNA therapy aims to disrupt the stabilization of key substrates including HIF-1α, SIRT1, and PTEN, thereby inhibiting pathological processes such as cardiac hypertrophy, cerebral ischemia/reperfusion injury, and tumor progression. Delivery of USP22 shRNA has been explored using adenoviral vectors and targeted nanoparticle systems like galactose-decorated lipopolyplexes (Gal-SLP).

Other names

USP22 short hairpin RNAUSP-22 short hairpin RNAUSP 22 short hairpin RNAshRNA-USP22shRNA-USP-22shRNA-USP 22