USP7 shRNA

USP7 shRNA is a gene-silencing therapeutic candidate designed to knock down the expression of Ubiquitin-specific-processing protease 7 (USP7), a deubiquitinating enzyme that is frequently upregulated in various cancers, including T-cell acute lymphoblastic leukemia (T-ALL). By utilizing RNA interference (RNAi), the shRNA reduces USP7 protein levels, which leads to the increased ubiquitination and subsequent degradation of its substrate, PHD Finger protein 8 (PHF8). The loss of PHF8 suppresses the expression of SNAI1 and inhibits the Wnt signaling pathway, ultimately inducing cell proliferation arrest and apoptosis in malignant cells. Preclinical studies using lentiviral delivery of USP7 shRNA have demonstrated significant anti-tumor activity in human T-ALL xenograft mouse models, characterized by reduced leukemia engraftment and decreased spleen involvement.

Other names

USP7 short hairpin RNAUSP-7 short hairpin RNAUSP 7 short hairpin RNAlentiviral shRNA targeting USP7