usual pain treatment-St. Olavs Hospital-postoperative pain

The drug name "usual pain treatment-St. Olavs Hospital-postoperative pain" refers to a specific multimodal analgesic regimen utilized as the standard of care at St. Olavs Hospital for managing postoperative pain, particularly following primary knee arthroplasty. This regimen is a combination of four distinct pharmacological agents: the corticosteroid dexamethasone, the non-opioid analgesic paracetamol (acetaminophen), and Vimovo, which is a fixed-dose combination of the non-steroidal anti-inflammatory drug (NSAID) naproxen and the proton pump inhibitor esomeprazole. The protocol involves a premedication phase with all four components, followed by postoperative maintenance with paracetamol and Vimovo. This combination targets multiple pain pathways: dexamethasone acts as a glucocorticoid receptor agonist to reduce systemic inflammation; paracetamol provides central analgesia; naproxen inhibits cyclooxygenase enzymes (COX-1 and COX-2) to reduce peripheral and central prostaglandin synthesis; and esomeprazole acts as an H+/K+ ATPase inhibitor to provide gastric protection against NSAID-induced mucosal injury.

Other names

dexamethasone + paracetamol + naproxen + esomeprazoleSt. Olavs Hospital multimodal analgesia protocolmultimodal analgesia regimen (St. Olavs Hospital)