Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
UThymoKidney
- Development stage
- Preclinical
- Lead developer
- United Therapeutics
- Administration
- Surgical Implantation
01
Overview
**UThymoKidney** is an investigational xenotransplantation product developed by United Therapeutics for **end-stage renal disease**. It consists of a kidney from a GalSafe donor pig carrying a single **GGTA1** gene knockout, transplanted together with thymus tissue from the same donor pig. Loss of alpha-1,3-galactosyltransferase prevents expression of the alpha-gal carbohydrate antigen, reducing a major source of immediate xenograft rejection; the accompanying thymic tissue is intended to promote recipient immune recognition of the graft as self and reduce rejection risk. The EXTEND program is evaluating its safety and efficacy in patients with ESRD. ([ir.unither.com](https://ir.unither.com/~/media/Files/U/United-Therapeutics-IR/documents/press-releases/2024/24-04-2024-bleecker.pdf))
- Other names
- GGTA1 KO ThymokidneyGGTA-1 KO ThymokidneyGGTA 1 KO ThymokidneyUThymoKidney
02
Targets
GGTA1 (Alpha-1,3-galactosyltransferase)
Beyond the preview
Go deeper on UThymoKidney.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on UThymoKidney.