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UV endonuclease from Micrococcus luteus
- Development stage
- Preclinical
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Topical
01
Overview
UV endonuclease from Micrococcus luteus is an enzyme purified from the bacterium Micrococcus luteus. It plays a crucial role in DNA repair by recognizing and acting upon DNA damaged by ultraviolet (UV) radiation. Specifically, it functions as a cyclobutane pyrimidine dimer (CPyD)–DNA glycosylase/abasic lyase, initiating the excision repair pathway by making single-strand breaks in UV-irradiated DNA at the sites of pyrimidine dimers. This enzyme has been investigated for its potential therapeutic applications in repairing UV-induced DNA damage in human cells, particularly in the context of preventing and treating skin conditions like actinic keratoses and skin cancers. It is often incorporated into topical formulations for dermatological use.
- Other names
- Endonuclease from Micrococcus luteusMicrococcus luteus UV endonucleasecyclobutane pyrimidine dimer-DNA glycosylase/abasic lyase
02
Targets
CPD (Cyclobutane pyrimidine dimer DNA lesion)
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