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UWD-00B
- Development stage
- Phase 1
- Lead developer
- Shenzhen Wandao Cell Technology
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
UWD-00B is a universal chimeric antigen receptor T cell (CAR-T) therapy targeting B-cell maturation antigen (BCMA). It is being developed for the treatment of refractory and relapsed multiple myeloma and plasma cell leukemia. The therapy involves engineering T cells to express a CAR that recognizes BCMA on malignant plasma cells, enabling targeted immune-mediated destruction of these cancerous cells. UWD-00B is described as "universal," indicating it may be designed for allogeneic use or with modifications to reduce immunogenicity and allow broader patient applicability. The drug is currently in early phase 1 clinical trials to evaluate its safety and preliminary efficacy[1][2].
- Other names
- Universal BCMA-Targeted CAR-TUniversal BCMA CAR-TREVO-UWD-00BREVO-UWD00BREVO-UWD 00B
02
Targets
BCMA (B-cell maturation antigen)
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