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UWN2D CAR-T

Development stage: Phase 1
Lead developer: Wugen
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

**UWN2D CAR-T** is an investigational NKG2D chimeric antigen receptor T-cell (CAR-T) therapy designed to target NKG2D ligands expressed on stressed or malignant cells. It redirects patient-derived T cells to recognize and eliminate tumor cells via the NKG2D receptor domain, which binds multiple stress-induced ligands such as MICA, MICB, and ULBPs, enabling broad antitumor activity independent of MHC presentation. Developed for oncology applications, it is being evaluated in a phase 1 pilot study for recurrent cancers.

Targets

MICA (Major histocompatibility complex class I-related protein A)MICB (Major histocompatibility complex class i-related protein B)NKG2D (Natural killer group 2 member D receptor)ULBP1 (UL16-binding protein 1)ULBP2 (UL16-binding protein 2)ULBP3 (UL16 binding protein 3)RAET1E (UL16-binding protein 4)ULBP5 (UL16-binding protein 5)ULBP6 (UL16-binding protein 6)

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