Drug intelligence / Profile preview

v1003

Development stage
Phase 4
Lead developer
Vernalis
Modality
Inhalation Devices → Device-based Delivery → Drug Delivery Systems, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Intranasal
01

Overview

V1003 is a novel, proprietary intranasal formulation of buprenorphine developed for the management of post-operative pain. Buprenorphine is a potent opioid analgesic that acts as a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. The intranasal delivery system was designed to provide rapid onset of pain relief suitable for both hospital and home settings. In clinical studies, V1003 demonstrated statistically significant superiority over placebo and even Vicodin (hydrocodone/acetaminophen) in certain dosing regimens for acute post-surgical pain relief. The most common adverse events were typical opioid-related effects such as nausea, vomiting, dizziness, and sleepiness[1][3][5][6].

Other names
Buprenorphine Sublingual Spray
02

Targets

MOR (Mu opioid receptor)KOR (Kappa opioid receptor)

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