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V118
- Development stage
- Phase 1
- Lead developer
- Merck
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
V118 is an investigational 31-valent pneumococcal conjugate vaccine (PCV31) developed by Merck & Co. (MSD). It is designed to provide broader protection against *Streptococcus pneumoniae* by targeting 31 different serotypes, expanding upon the coverage provided by earlier generation vaccines such as V114 (15-valent) and V116 (21-valent). The vaccine utilizes a conjugate technology where capsular polysaccharides from each of the 31 serotypes are linked to a carrier protein to induce a T-cell dependent immune response, which is intended to be effective across various age groups, including infants and older adults. V118 is currently in Phase 2 clinical development for the prevention of pneumococcal disease.
- Other names
- PCV31PCV-31PCV 3131-valent pneumococcal conjugate vaccine
02
Targets
CPS (Streptococcus pneumoniae capsular polysaccharide)
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