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V3G CH848 Pr-NP1
- Development stage
- Phase 1
- Lead developer
- National Institute of Allergy and Infectious Diseases
- Modality
- Nanoparticles → Drug Delivery Systems, Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
V3G CH848 Pr-NP1 is an investigational prophylactic HIV-1 vaccine prime immunogen developed by the National Institute of Allergy and Infectious Diseases. It is a ferritin nanoparticle displaying eight copies of a native-like HIV-1 envelope trimer designed to initiate B-cell responses that can mature into V3-glycan-specific broadly neutralizing antibodies against HIV-1. It is being evaluated in a first-in-human Phase 1 prime-boost study in adults without HIV, with later boosting by the distinct mRNA-LNP immunogen V3G CH848 mRNA-Tr2. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05903339))
- Other names
- V3G + CH848 + Pr-NP1
02
Targets
gp120 (HIV-1 envelope glycoprotein (gp120/gp41) epitopes)
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