Drug intelligence / Profile preview

V710

Development stage
Phase 3
Lead developer
Merck
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

V710 is an investigational vaccine developed for the prevention of *Staphylococcus aureus* infections. The vaccine contains a highly conserved protein antigen, iron surface determinant B (IsdB), from *S. aureus*, designed to elicit an immune response and generate protective antibodies against the bacterium. Developed through a collaboration between Intercell and Merck, V710 was evaluated in multiple clinical trials for its safety and immunogenicity in populations at high risk for *S. aureus* infection, such as patients undergoing cardiothoracic surgery or hemodialysis. While it demonstrated the ability to induce immune responses in these populations, a large Phase II/III trial was terminated after interim analysis indicated that significant clinical benefit would not be achieved.

Brand names
V710V-710V 710
Other names
V710 + AAHSV710 + amorphous aluminum hydroxyphosphate sulfate
02

Targets

IsdB (Iron surface determinant B)

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