VA03

VA03 is a small molecule inhibitor specifically targeting **Galectin-3 (Gal-3)**, a member of the lectin family that binds β-galactosides. Galectin-3 is frequently overexpressed in various malignancies and plays a critical role in cell-cell adhesion, cell-matrix interactions, inflammation, and cancer progression. In oncological research, particularly in androgen-independent prostate cancer models (such as the DU-145 cell line), VA03 has been shown to inhibit tumor cell migration and invasion. Its mechanism involves disrupting the signaling complexes and molecular signatures regulated by estrogen receptors (ERα and ERβ) that promote metastatic potential. VA03 is primarily utilized as a pharmacological tool in preclinical research to elucidate the molecular mechanisms of cancer progression and to evaluate Galectin-3 as a potential therapeutic target.

Other names

Galectin-3 inhibitor VA03Galectin3 inhibitor VA03Galectin 3 inhibitor VA03