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Vaginal microbiota transplant
- Development stage
- Unknown
- Lead developer
- Douglas Kwon
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Vaginal
01
Overview
Vaginal microbiota transplant (VMT) is an investigational biological therapy being developed by Douglas Kwon and Caroline Mitchell for the treatment of recurrent bacterial vaginosis (BV). The therapy involves the transfer of the entire vaginal microbial community from healthy, Lactobacillus-dominant donors into patients with BV following a course of antibiotic treatment (typically metronidazole). The goal of the transplant is to achieve stable engraftment of beneficial bacteria, particularly *Lactobacillus crispatus*, to restore a healthy vaginal ecosystem, reduce inflammation, and prevent the recurrence of dysbiosis. It is currently being evaluated in the Phase 1/2 MOTIF trial (NCT04046900) and is regulated by the FDA as a live biotherapeutic product under Investigational New Drug (IND) status.
- Other names
- Vaginal microbiome transplant
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