valerian root dry extract

Valerian root dry extract, derived from the roots of *Valeriana officinalis*, is a herbal preparation widely utilized for its sedative, anxiolytic, and sleep-promoting properties. Its pharmacological activity is primarily attributed to constituents such as valerenic acids, valepotriates, and flavonoids, which interact with the central nervous system's GABAergic pathways. Specifically, valerenic acid acts as a positive allosteric modulator of GABA-A receptors and inhibits the enzyme GABA transaminase, leading to increased synaptic concentrations of GABA and subsequent CNS depression. Researchers at the Medical University of Graz have specifically investigated the use of standardized valerian root dry extract for the prevention and management of perioperative anxiety and pain, positioning it as a potential natural alternative to benzodiazepines in the surgical setting. It is also commonly marketed globally as a traditional herbal medicine or dietary supplement for insomnia and restlessness.

Brand names

ValmaneSedoniumValdispertBaldriparan

Other names

Valeriana officinalis root extractValerian extractValerian dry extract