Drug intelligence / Profile preview

valerylfentanyl

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Inhalation, Intravenous, Intranasal
01

Overview

Valerylfentanyl is an illicit synthetic opioid and a structural analog of fentanyl, characterized by the addition of a valeryl (pentanoyl) group. It functions as an agonist at the mu-opioid receptor, producing pharmacological effects similar to other fentanyl-related compounds, including analgesia, sedation, and potentially fatal respiratory depression. First detected in illicit drug markets around 2016, valerylfentanyl has no recognized therapeutic applications and is not produced by legitimate pharmaceutical manufacturers. It is classified as a Schedule I controlled substance in the United States and is monitored globally as a new psychoactive substance (NPS) due to its role in the ongoing opioid overdose crisis.

Other names
pentanoylfentanylN-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]pentanamide
02

Targets

DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)

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