Valpromide

Valpromide is a carboxamide derivative of valproic acid and acts as a prodrug for valproic acid. It is used primarily in the treatment of epilepsy and as an adjunct therapy for psychomotor agitation, depression, and manic episodes associated with bipolar disorder. After oral administration, it is rapidly metabolized (about 80%) to valproic acid but also possesses intrinsic anticonvulsant activity. Its mechanism of action involves increasing GABA levels in the brain and altering neuronal membrane conductance, contributing to its antiepileptic and mood-stabilizing effects. Valpromide inhibits liver microsomal epoxide hydrolase much more potently than valproic acid, which can lead to significant drug interactions (notably with carbamazepine). It may provide more stable plasma levels than other forms of valproate but shares similar safety concerns during pregnancy[1][2][4][5][8].

Brand names

Depamide

Other names

ValpromidaDipropylacetamide