valsartan + amlodipine + chlorthalidone

This drug is a **fixed-dose combination** of three antihypertensive agents: valsartan, amlodipine, and chlorthalidone. - **Valsartan** is an angiotensin II receptor blocker (ARB) that inhibits the action of angiotensin II on the AT1 receptor, leading to vasodilation and reduced blood pressure. - **Amlodipine** is a dihydropyridine calcium channel blocker that inhibits L-type calcium channels in vascular smooth muscle, causing arterial vasodilation and reduction in blood pressure. - **Chlorthalidone** is a thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubule of the nephron, promoting diuresis and reducing blood volume and blood pressure. This triple combination is typically used for the treatment of **hypertension**, especially in patients who require multiple antihypertensive agents to achieve target blood pressure levels. Most commonly, fixed combinations available in the market substitute chlorthalidone with hydrochlorothiazide in similar triple therapies, but the pharmacologic effects are considered clinically similar.

Other names

valsartan + amlodipine + chlorthalidone