Drug intelligence / Profile preview

valsartan + levamlodipine (Beijing Sun-Novo Pharmaceutical Research Co., Ltd.)

Development stage
Unknown
Lead developer
Sun-Novo
Modality
Small Molecules
Administration
Oral
01

Overview

**NHKC-1** is an oral fixed-dose antihypertensive combination of **valsartan** and **levamlodipine** being developed in China for primary hypertension, including patients whose blood pressure is inadequately controlled with antihypertensive monotherapy. Valsartan is a selective angiotensin II type 1 receptor antagonist that reduces angiotensin-II-mediated vasoconstriction and aldosterone effects, while levamlodipine is the active S-enantiomer of amlodipine, a dihydropyridine L-type calcium-channel blocker that promotes arterial vasodilation. The product has been evaluated as an 80 mg/2.5 mg oral tablet in Chinese clinical studies.

Other names
valsartan/levamlodipine缬沙坦左氨氯地平片
02

Targets

AGTR1 (Angiotensin II Type-1 receptor)LTCC (Voltage-gated calcium channel (L-type))

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