Drug intelligence / Profile preview

valsartan + Mudan Granules

Development stage
Unknown
Modality
Drug Delivery Systems, Small Molecules
Administration
Oral
01

Overview

Valsartan + Mudan Granules is a combination therapy consisting of valsartan, a small molecule angiotensin II receptor blocker (ARB), and Mudan Granules, a traditional Chinese medicine formulation. Valsartan selectively blocks the angiotensin II type 1 (AT1) receptor, leading to vasodilation and reduced blood pressure without affecting heart rate. It is primarily used for the treatment of mild to moderate essential hypertension[2][9]. Mudan Granules are composed of various herbal ingredients such as Corydalis yanhusuo, Panax notoginseng, Paeonia rubra, Salvia miltiorrhiza, Ligusticum chuanxiong, Carthamus tinctorius (safflower), Sappanwood, and Millettia dielsiana. The granules are indicated for diabetic peripheral neuropathy with symptoms like numbness and pain in extremities due to Qi deficiency and blood stasis; their mechanism involves promoting circulation ("invigorating Qi" and "activating blood"), unblocking channels ("tongluo"), and relieving pain[4][8]. The combination aims to address both hypertension (via valsartan) and microvascular or neuropathic complications often seen in metabolic diseases (via Mudan Granules).

Other names
缬沙坦和木丹颗粒
02

Targets

AGTR1 (Angiotensin II Type-1 receptor)

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