vancomycin

Vancomycin is a glycopeptide antibiotic used primarily to treat serious or life-threatening infections caused by Gram-positive bacteria that are unresponsive to other antibiotics. It is especially important in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile-associated colitis. Vancomycin works by inhibiting bacterial cell wall synthesis through binding to the D-alanyl-D-alanine terminus of cell wall precursor units, thereby preventing cross-linking and weakening the bacterial cell wall. This action leads to bacterial cell death. In addition to its primary mechanism, vancomycin may also alter membrane permeability and inhibit RNA synthesis in susceptible organisms. The drug is not active against Gram-negative bacteria due to their outer membrane barrier[2][3][5][6][7][8]. Vancomycin was originally derived from Streptomyces orientalis.

Brand names

FirvanqVancocinFIRST-Vancomycin 25FIRST-Vancomycin25FIRST-Vancomycin-25FIRST-Vancomycin 50FIRST-Vancomycin50FIRST-Vancomycin-50Vancoled

Other names

vancomycin, monohydrochloride