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Vanguard Plus 5 is a multivalent veterinary vaccine developed by Zoetis (formerly Pfizer Animal Health) for the immunization of healthy dogs aged 6 weeks or older. It is a lyophilized (freeze-dried) preparation containing live attenuated strains of canine distemper (CD) virus, canine adenovirus type 2 (CAV-2), canine parainfluenza (CPI) virus, and canine parvovirus (CPV). The vaccine is specifically formulated with a high-titer, low-passage CPV strain designed to be highly immunogenic and capable of overcoming maternal antibody interference in young puppies. It provides protection against canine distemper, infectious canine hepatitis (caused by CAV-1), respiratory disease (caused by CAV-2), canine parainfluenza, and canine parvoviral enteritis (including disease caused by CPV-2c).
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