Drug intelligence / Profile preview

vanillyl butyl ether

Development stage
Unknown
Modality
Small Molecules
Administration
Topical, Oral
01

Overview

Vanillyl butyl ether is a synthetic organic compound derived from vanillin and modified with a butyl ether group. It is primarily used as a warming agent in cosmetics and personal care products due to its ability to activate the transient receptor potential vanilloid 1 (TRPV1) channel, which induces a warming sensation on the skin. This mechanism mimics the effect of capsaicin but with less irritation. Vanillyl butyl ether is also used as a flavoring agent in food products and as a fragrance ingredient in various formulations. Its applications include topical analgesics, sports balms, cellulite treatments, oral care agents, hair conditioning agents, and other sensory-enhancing cosmetic products[1][3][5][6][7]. The compound is oil-soluble and stable in emulsions; it provides an immediate warming effect that can last up to two hours[6]. It does not contain animal-derived components and is considered non-comedogenic[7].

Brand names
HotactHOTACT VBE
Other names
4-(butoxymethyl)-2-methoxyphenolbutyl vanillyl etherphenol 4-(butoxymethyl)-2-methoxy-VBE
02

Targets

TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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