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vantictumab + nab-paclitaxel + gemcitabine
- Development stage
- Discontinued
- Lead developer
- Mereo BioPharma
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
This combination comprises **vantictumab** (a fully human monoclonal antibody and Wnt signaling pathway inhibitor that targets the Frizzled family receptors FZD1, FZD2, FZD5, FZD7, and FZD8), **nab-paclitaxel** (an albumin-bound formulation of paclitaxel), and **gemcitabine** (a nucleoside analog used as chemotherapy)[3][4]. It has been investigated in phase 1b studies for the treatment of untreated metastatic pancreatic adenocarcinoma, aiming to augment cytotoxic chemotherapy by also targeting cancer stem cell pathways (through Wnt inhibition)[1][3][4]. Early clinical results showed partial responses and disease stabilization in some patients, but development was halted due to bone-related adverse events linked to vantictumab[3][4]. Vantictumab was developed by OncoMed Pharmaceuticals and the combination was tested in studies sponsored by OncoMed Pharmaceuticals and later, Mereo BioPharma[4][5].
- Other names
- vantictumab + nab-paclitaxel + gemcitabine
02
Targets
RNR (Ribonucleotide reductase)FZD8 (Frizzled Receptor 8)DNA polymerase familyFZD7 (Frizzled class receptor 7)FZD5 (Frizzled receptor 5)FZD1 (Frizzled Receptor 1)FZD2 (Frizzled Receptor 2)TUBB (Tubulin (alpha and beta subunits))
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