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vapiprost
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Vapiprost is a small molecule, orally available thromboxane A2 receptor (TBXA2R) antagonist. It acts by inhibiting the action of thromboxane A2, a prostanoid involved in platelet aggregation and vasoconstriction, making it an antithrombotic agent. Vapiprost was originally developed for cardiovascular diseases such as thrombosis, myocardial ischemia, and coronary restenosis. Clinical studies demonstrated its efficacy in inhibiting platelet aggregation, maintaining vascular patency after thrombolysis, and prolonging time to arterial occlusion. Vapiprost’s pharmacological effects are rapid but relatively short-acting, and the drug was discontinued before reaching the market[1][2][3][4][5][7][9].
- Brand names
- vapiprostvapiprost hydrochloride
- Other names
- vapiprost hydrochlorideGR-32191GR32191GR 32191GR-32191BGR32191BGR 32191BSN-309SN309SN 309
02
Targets
TYMP (Thymidine phosphorylase)
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