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varicella virus vaccine live new seed process + measles, mumps, and rubella virus vaccine live
- Development stage
- Approved
- Lead developer
- Merck
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous, Intramuscular
01
Overview
A **combination vaccine** containing two live attenuated virus vaccine components: - **Varicella virus vaccine live new seed process** (typically derived from the Oka strain via cell culture adaptation and serial passage, with the "new seed process" referring to updated manufacturing or seed-lot methodologies using designated master and working seed stocks[2][4][6]). - **Measles, mumps, and rubella virus vaccine live** (MMR), using attenuated strains from measles (commonly Edmonston strain), mumps (often Jeryl Lynn strain), and rubella (usually RA27/3 strain)[5]. This vaccine induces the host's immune system to generate protective antibodies against all four viruses (measles, mumps, rubella, varicella)[1][3][7]. Its mechanism is the stimulation of active, long-term immunity by presenting antigens derived from weakened viruses, promoting both humoral and cellular immune responses. It is indicated for the prevention of infection by measles, mumps, rubella, and varicella zoster (chickenpox) viruses in children or susceptible adults[1][3][7].
- Brand names
- ProQuadPriorix Tetra
- Other names
- measles, mumps, rubella, and varicella virus vaccine live
02
Targets
RUBV C (Rubella virus capsid protein)
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