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Drug intelligence / Profile preview
Vascanox HP
- Development stage
- Unknown
- Lead developer
- Calroy Health Sciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Vascanox HP is an encapsulated nutraceutical formulation developed by Calroy Health Sciences, designed to support cardiovascular health and blood pressure management. The product combines two key active components: S-allylcysteine (SAC), a sulfur-containing amino acid derived from garlic, and dietary inorganic nitrate. Its mechanism of action involves the modulation of the nitric oxide (NO) and hydrogen sulfide (H2S) gasotransmitter pathways. Specifically, it enhances NO bioavailability through the non-canonical nitrate-nitrite-nitric oxide pathway, while SAC serves as a precursor for H2S, which is believed to influence NO biosynthesis and metabolism. Vascanox HP has been evaluated in clinical settings for its efficacy in reducing elevated blood pressure and managing mild-to-moderate hypertension.
- Brand names
- Vascanox HP
- Other names
- S-allylcysteine-rich garlic extract + dietary inorganic nitrateSAC-rich garlic extract + nitrate
02
Targets
ACE (Angiotensin Converting Enzyme)NOS3 (eNOS)PDE5 (Phosphodiesterase 5A)sGC (Soluble Guanylyl Cyclase)Vascular smooth muscle potassium channelH2S (Hydrogen sulfide)NO2- (Nitrite)
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