vascular endothelial growth factor receptor 1 fc

Vascular endothelial growth factor receptor 1 fc (VEGFR1-Fc), also known as Flt1-Fc, is a recombinant fusion protein consisting of the extracellular ligand-binding domain (specifically domain 2) of human VEGFR1 fused to the Fc region of human IgG1. It functions as a high-affinity 'VEGF trap' by binding to and neutralizing vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor B (VEGF-B), and placental growth factor (PlGF). By sequestering these ligands, VEGFR1-Fc prevents their interaction with native cell-surface receptors, thereby inhibiting angiogenesis, reducing vascular permeability, and suppressing tumor growth. In oncology, candidates like ImmuneOnco's IMM25 have been developed to deprive tumors of their blood supply. Additionally, VEGFR1-Fc has been investigated for the treatment of preeclampsia, where it aims to sequester excess circulating sFlt-1 or its ligands. The VEGFR1 domain 2 moiety is also a critical component of more complex biologics, such as the anti-PD-L1/VEGF bispecific antibody IMM2510.

Other names

VEGFR1-Fc fusion proteinVEGFR-1-Fc fusion proteinVEGFR 1-Fc fusion proteinFlt1-Fc fusion proteinFlt-1-Fc fusion proteinFlt 1-Fc fusion proteinVEGF Trap R1