vascular endothelial growth factor small interfering RNA

Vascular endothelial growth factor small interfering RNA is an **RNA-based therapeutic that targets vascular endothelial growth factor (VEGF) mRNA** for degradation, leading to suppression of VEGF protein expression. VEGF is a key mediator of angiogenesis in both normal and pathological conditions, including cancer and ocular neovascularization. By employing the RNA interference pathway, small interfering RNAs (siRNAs) specifically bind to and induce the cleavage of VEGF mRNA, thereby reducing VEGF protein levels. Preclinical studies have demonstrated **reduction of tumor cell proliferation and angiogenesis in models of hepatocellular carcinoma, colon cancer, and choroidal neovascularization**, typically via direct local administration (intravitreal injection for ocular disease, transarterial embolization or transfection for tumor models). Delivery systems and siRNA sequence design are critical to efficacy and minimizing toxicity[1][2][3].

Other names

VEGF siRNAanti-VEGF siRNAVEGF-targeted siRNAsiRNA targeting vascular endothelial growth factor