vasopressin + methylprednisolone + hydrocortisone

This is a **combination therapy** of three drugs: **vasopressin**, **methylprednisolone**, and **hydrocortisone**. It has been investigated mainly as part of protocols for improving outcomes in **in-hospital cardiac arrest**, typically administered alongside standard treatments (e.g., adrenaline/epinephrine). Vasopressin is a peptide hormone with potent vasoconstrictive properties, methylprednisolone and hydrocortisone are synthetic glucocorticoid corticosteroids used for their anti-inflammatory and hemodynamic-stabilizing effects. Clinical trials have studied the bundle, often giving vasopressin and methylprednisolone during resuscitation and hydrocortisone as an infusion for post-resuscitation shock. The combined use aims to increase return of spontaneous circulation (ROSC), survival, and maintain hemodynamic stability in critically ill patients[1][4][5].

Other names

Vasopressin and Steroids in Cardiac ArrestVAST-A intervention