Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
VASP shRNA
- Development stage
- Preclinical
- Lead developer
- University of Minnesota
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
VASP shRNA is a gene-silencing therapeutic candidate designed to knock down the expression of vasodilator-stimulated phosphoprotein (VASP) via RNA interference. VASP is an actin-binding protein that promotes the β1-integrin-FAK-YAP1/TAZ signaling axis, a pathway critical for the colonization and growth of gastrointestinal (GI) cancer cells in the liver. By reducing VASP levels, this shRNA inhibits cancer cell attachment, migration, and proliferation in the liver parenchyma. Preclinical research conducted by institutions including the University of Minnesota and Mayo Clinic has demonstrated that VASP knockdown suppresses liver metastasis in mouse models of colorectal and pancreatic cancer, suggesting its potential as a therapeutic target for advanced GI malignancies.
- Other names
- vasodilator-stimulated phosphoprotein shRNAvasodilator-stimulated phosphoprotein short hairpin RNA
02
Targets
VASP (Vasodilator-stimulated phosphoprotein)
Beyond the preview
Go deeper on VASP shRNA.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on VASP shRNA.