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Drug intelligence / Profile preview
vault-based coronavirus vaccine
- Development stage
- Preclinical
- Lead developer
- VaultPharma
- Modality
- Vaccines & Immunotherapeutics, Nanoparticles → Drug Delivery Systems
01
Overview
The vault-based coronavirus vaccine is an experimental **nanoparticle biologic vaccine** being developed by Vault Pharma for prevention of COVID-19. It uses genetically engineered **vault nanoparticles**, which are naturally occurring barrel-shaped ribonucleoprotein particles found in human cells, as a delivery platform to package and present **coronavirus proteins** to the immune system. The intended mechanism is to induce both **humoral** and **cellular immune responses** against SARS-CoV-2, with the goal of functioning as a second-generation coronavirus vaccine and potentially also supporting therapeutic immune activation. Based on the provided information, the program remained **preclinical** and had not yet entered human testing.
- Other names
- vault-based coronavirus vaccinevault-based COVID-19 vaccinevault nanoparticle coronavirus vaccine
02
Targets
Spike-ACE2 PPI (SARS-CoV-2 spike–ACE2 interface)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)RBD (SARS-CoV-2 spike receptor-binding domain)
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