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**VAX-31** is Vaxcyte's investigational 31-valent pneumococcal conjugate vaccine designed to prevent disease caused by *Streptococcus pneumoniae*, including invasive pneumococcal disease and pneumococcal pneumonia. It presents capsular polysaccharide antigens from 31 pneumococcal serotypes as conjugates using Vaxcyte's carrier-sparing platform, with the goal of eliciting serotype-specific functional antibodies and opsonophagocytic killing of pneumococci. VAX-31 is in a Phase 3 adult OPUS program and a Phase 2 infant program; it is not approved for use. ([vaxcyte.com](https://vaxcyte.com/pipeline/))
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