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VAX172
- Development stage
- Unknown
- Lead developer
- VaxInnate
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
VAX172 is a recombinant fusion protein vaccine candidate designed to provide protection against influenza B viruses of the Victoria lineage. Developed by VaxInnate, the molecule consists of the globular head of the influenza hemagglutinin (HA) protein genetically fused to flagellin, a ligand for Toll-like receptor 5 (TLR5). This design utilizes flagellin as an intrinsic adjuvant to stimulate the innate immune system and enhance the adaptive response to the HA antigen. VAX172 was evaluated in clinical trials as a constituent of VAX2012Q, a quadrivalent seasonal influenza vaccine. The platform aims to improve vaccine efficacy and manufacturing speed compared to traditional egg-based methods by utilizing recombinant protein expression in bacterial systems.
- Other names
- B/Victoria hemagglutinin-flagellin fusion proteinVAX172 (B-VIC)
02
Targets
HA (Hemagglutinin)TLR5
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