VB-8

VB-8 is a synthetic small molecule compound identified as a potent dual inhibitor of Acetylcholinesterase (AChE) and Monoamine oxidase A (MAO-A). It belongs to a class of propargyl-containing 4,6-diphenylpyrimidine derivatives. In preclinical studies, VB-8 demonstrated significant neuroprotective properties against 6-OHDA- and H2O2-induced neurotoxicity in SH-SY5Y cells and was found to be non-toxic to these human neuroblastoma cells at concentrations up to 25 μM. Molecular dynamics simulations indicated that VB-8 is stable within the hydrophobic cavities of both MAO-A and AChE enzymes. This compound is being investigated as a potential therapeutic lead for the treatment of Alzheimer's disease, a neurodegenerative disorder characterized by multifactorial pathogenesis.