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VB10.2210
- Development stage
- Phase 2
- Lead developer
- Nykode Therapeutics
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
VB10.2210 is a novel SARS-CoV-2 vaccine candidate designed to induce broad and strong T cell responses, particularly dominated by killer CD8 T cells, against both Spike and non-Spike antigens of the virus. It encodes 96 clinically validated T cell epitopes spanning eight SARS-CoV-2 proteins, including Spike, Membrane Glycoprotein (M), Nucleocapsid Protein (N), Orf1ab+Orf3+Orf10, and Orf7. The vaccine is intended to provide protection that remains effective across variants of concern due to its targeting of highly conserved non-Spike epitopes less affected by mutational drift[2][4][6]. VB10.2210 uses Nykode Therapeutics’ Vaccibody™ technology platform for antigen presentation.
- Other names
- Nykode COVID-19 T-cell vaccineAdaptive-Nykode vaccinecoronavirus t cell adaptive vaccine
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