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VB5-845D-800CW

Development stage: Unknown
Lead developer: Carisma Therapeutics Inc
Modality: Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

VB5-845D-800CW is an investigational near-infrared (NIR) fluorescent imaging agent designed for intraoperative fluorescence-guided surgery. It consists of a Fab-fragment antibody (derived from the VB6-845 series) that specifically targets the epithelial cell adhesion molecule (EpCAM), conjugated to the NIR fluorescent dye IRDye800CW. EpCAM is highly overexpressed in various epithelial malignancies, including colorectal, oesophageal, and gastric cancers. By binding to tumor cells, the agent allows surgeons to visualize tumor margins and detect occult lesions in real-time using NIR imaging systems. It is currently being evaluated in Phase I clinical trials for the detection of gastrointestinal cancers.

Other names: VB5-845D-IRDye800CWVB-5-845D-IRDye800CWVB 5-845D-IRDye800CW

Targets

EPCAM (Epithelial cell adhesion molecule)

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