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Drug intelligence / Profile preview
vB_AbM_HMGU
- Development stage
- Preclinical
- Lead developer
- Helmholtz Munich
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
01
Overview
vB_AbM_HMGU is a lytic bacteriophage targeting multidrug-resistant *Acinetobacter baumannii* biofilms. Developed by Helmholtz Munich and the Technical University of Munich, this phage encodes unique ribosomal and transcriptional regulatory proteins that counteract the translation-inhibiting effects of macrolide antibiotics, thereby enhancing biofilm degradation and showing synergistic activity when combined with macrolides. Additionally, infection with vB_AbM_HMGU induces beneficial mutations in the host bacterium, reducing virulence and restoring antibiotic susceptibility.
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