Drug intelligence / Profile preview

VBI-160

Development stage
Preclinical
Lead developer
Kansas City University
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Intravenous
01

Overview

VBI-160 is a proprietary phospholipid nanoparticle-based fluid developed for the treatment of severe hemorrhagic shock and resuscitation from clinical death. It is a reformulated version of VBI-1, specifically designed with a lower concentration of egg lecithin to prevent the impairment of coagulation (prolonged bleeding time) observed with the original formulation. VBI-160 is intended to inhibit ischemia-reperfusion injury and facilitate the rapid recovery of motor and cognitive functions following extreme blood loss. Preclinical studies in rat models have demonstrated that VBI-160 significantly improves hemostasis compared to VBI-1 while maintaining its therapeutic efficacy.

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