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VBS-102

Development stage: Preclinical
Lead developer: Ollin Biosciences
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

VBS-102 is a preclinical-stage bispecific antibody developed by Velavigo Shanghai Pharmaceutical for the treatment of thyroid eye disease (TED). It is designed to simultaneously target the insulin-like growth factor 1 receptor (IGF-1R) and the thyroid-stimulating hormone receptor (TSHR), two key pathways implicated in the pathogenesis of TED. By modulating the signaling of these receptors, VBS-102 aims to reduce the inflammation and tissue remodeling associated with the disease. In 2024, Velavigo entered into a global licensing agreement (excluding Greater China) with Ollin Biosciences for the development and commercialization of VBS-102 for up to $440 million.

Other names: VBS-102VBS102VBS 102

Targets

TSHR (Thyroid-stimulating hormone receptor)IGF-1R (Insulin-like growth factor 1 receptor)

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