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VCB-1502

Development stage: Preclinical
Lead developer: Vaxcell-Bio Therapeutics
Modality: Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Ophthalmic

Overview

VCB-1502 is a nanobody-based anti-angiogenic therapeutic being developed by Vaxcell-Bio Therapeutics for the treatment of macular degeneration. The drug functions by binding to vascular endothelial growth factor (VEGF) and blocking its interaction with the VEGF receptor (VEGFR), thereby inhibiting pathological neovascularization. Due to its nanobody structure, VCB-1502 is significantly smaller than conventional antibodies, which may provide superior intraocular permeability and allow for more versatile drug delivery system (DDS)-based administration routes, including potential non-invasive delivery. Vaxcell-Bio Therapeutics is co-developing a DDS formulation for this therapy in partnership with Seoul National University.

Other names: Anti-angiogenic inhibitor

Targets

VEGFA (Vascular endothelial growth factor A)

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