vd-hemopressin-alpha

VD-hemopressin-alpha is an **11-residue peptide** derived from the α1 chain of hemoglobin, with the sequence VDPVNFKLLSH[3][1]. It acts as a **selective agonist of the CB1 cannabinoid receptor**, engaging intracellular signaling pathways such as increasing Ca²⁺ release and ERK phosphorylation[1][3][5]. VD-hemopressin-alpha is a member of the cannabinopeptide class and has been shown to induce **analgesia** (pain inhibition) in animal models when injected into the brain, and also to **promote non-rapid eye movement (NREM) sleep** via CB1 receptor activation[1][3][5]. Effects have been demonstrated on pain thresholds and EEG patterns, likely via activation of VLPO GABAergic neurons and inhibition of orexinergic, noradrenergic, and histaminergic neurons[3][5].

Other names

VD-hemopressin-alphaVD-hemopressin (α)(m)VD-hemopressin (α)VD-HPα